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Groningen Research Initiative on able Ageing and Immune Longevity (GRAIL), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.The activation scores the diagnosis subgroups differ barely teenager region with the lowest scores attained sooner than the gloominess and anxiety group.